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June
2023
- Volume 17, Issue 1
Depression
causes various inflammatory processes in human body
Mehmet Rami Helvaci
1, Esra Candan 2, Ayse Ceylan 2, Huseyin Sencan 1,
Abdulrazak Abyad 3, Lesley Pocock 4
(1) Specialist of Internal Medicine,
MD, Turkey
(2) Manager of Writing and Statistics, Turkey
(3) Middle-East Academy for Medicine of Aging, MD, Lebanon
(4) medi-WORLD International, Australia
Correspondencing author
Prof Dr Mehmet Rami Helvaci, MD
07400, ALANYA, TurkeyPhone: 00-90-506-4708759
Email: mramihelvaci@hotmail.com
Received: April 2023; Accepted: May
2023; Published: June 2023
Citation: Mehmet Rami Helvaci et al. Depression causes various
inflammatory processes in human body. Middle East Journal
of Nursing 2023; 17(1): 31-41 DOI: 10.5742/MEJN2023.9378032
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ABSTRACT
Background:
We tried to understand whether or not there are some relationships
between irritable bowel syndrome (IBS), chronic gastritis
(CG), depression, and various inflammatory processes in the
body.
Method: Consecutive patients
with IBS and age and sex-matched control cases were included.
Results: The study included
936 patients with IBS (592 females) and 346 control cases.
Mean age of the patients was 41.0 years, and 63.2% of them
were female. Although gastric sample biopsies were taken just
in suspected cases, CG was diagnosed nearly in all of the
patients with the IBS (80.4% vs 15.0%, p<0.001). Interestingly,
prevalence of antidepressants use was also higher in the IBS
cases, significantly (46.4% vs 16.1%, p<0.001). Similarly,
smoking (35.2% vs 20.8%, p<0.001), hemorrhoids (37.1% vs
7.2%, p<0.001), and urolithiasis (22.0% vs 9.5%, p<0.001)
were all higher in the IBS patients, again. Beside that the
mean values of fasting plasma glucose (FPG) (111.9 vs 105.4
mg/dL, p= 0.002) and plasma triglycerides (167.0 vs 147.3
mg/dL, p= 0.013) were also higher in the IBS patients, significantly.
Conclusion: Because FPG and
triglycerides are well-known acute phase reactants in the
body, IBS and CG may be some low-grade inflammatory processes
initiated with anxiety, depression, infection, inflammation,
trauma, and cancer fear-like stresses of the body, and eventually
terminate with hemorrhoids and urolithiasis. Due to the highly
significant associations between IBS, CG, and depression,
IBS and CG may actually be the two sides of the same paper,
and just be two examples of depression-induced various inflammatory
processes in human body.
Key words: Depression, irritable
bowel syndrome, chronic gastritis, irritable gastrointestinal
syndrome, smoking, fasting plasma glucose, triglycerides
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