Chronic inflammatory processes may prevent malignancies

Mehmet Rami Helvaci1, Saziye Cayir2, Hulya Halici2, Alper Sevinc1, Celaletdin Camci1, Abdulrazak Abyad3, Lesley Pocock4

(1) Specialist of Internal Medicine, MD, Turkey
(2) Manager of Writing and Statistics, Turkey
(3) Middle-East Academy for Medicine of Aging, MD, Lebanon
(4) medi-WORLD International, Australia

Corresponding author:
Prof Dr Mehmet Rami Helvaci, MD
07400, ALANYA, Turkey
Phone: 00-90-506-4708759
Email: mramihelvaci@hotmail.com

Received: May 2024; Accepted: June 2024; Published: July 2024
Citation: Helvaci MR et al. Chronic inflammatory processes may prevent malignancies. Middle East Journal of Nursing 2024; 18(2): 11-28. DOI: 10.5742/MEJN2024.9378052

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ABSTRACT

Background: The hardened red blood cells-induced capillary endothelial damage is initiated at birth, and terminate with accelerated atherosclerosis, multiorgan failures, and sudden death even at childhood in sickle cell diseases (SCD).

Methods: All cases with the SCD were included.

Results: We studied 222 males and 212 females with similar mean ages (30.8 vs 30.3 years, p>0.05, respectively). Disseminated teeth losses (5.4% vs 1.4%, p<0.001), ileus (7.2% vs 1.4%, p<0.001), cirrhosis (8.1% vs 1.8%, p<0.001), leg ulcers (19.8% vs 7.0%, p<0.001), digital clubbing (14.8% vs 6.6%, p<0.001), coronary heart disease (18.0% vs 13.2%, p<0.05), chronic renal disease (9.9% vs 6.1%, p<0.05), chronic obstructive pulmonary disease (25.2% vs 7.0%, p<0.001), and stroke-like atherosclerotic endpoints (12.1% vs 7.5%, p<0.05) were all higher but not acute chest syndrome (2.7% vs 3.7%, p>0.05) or pulmonary hypertension (12.6% vs 11.7%, p>0.05) or deep venous thrombosis and/or varices and/or telangiectasias (9.0% vs 6.6%, p>0.05) in males. Although the higher prevalences of acute and chronic inflammatory processes and atherosclerotic consequences even in relatively younger mean ages in both genders, there was no case of malignancy neither in males nor in females in SCD.

Conclusion: Infections, medical or surgical emergencies, or emotional stress-induced increased basal metabolic rate aggravates the sickling and capillary endothelial inflammation and edema, and terminates with disseminated tissue hypoxia, accelerated atherosclerosis, multiorgan failures, and sudden deaths even at relatively younger mean ages but not malignancies in the SCD. In another definition, chronic and systemic inflammatory processes may increase the clearance of malignant cells from the circulation.

Key words: Sickle cell diseases, chronic inflammations, hardened red blood cells, capillary endothelial inflammation, tissue hypoxia, atherosclerosis, malignancies